Salamanchuk Z Ia, Masliak Z V, Lozyns'ka M R, Vyhovs'ka Ia I, Lohins'kyĭ V Ie, Male P
Tsitol Genet. 1998 Jan-Feb;32(1):43-8.
Cytogenetic investigations, including the analysis of karyotype indicated by G-banding and FISH for Ph chromosome, were performed in the patients with myelodysplastic syndrome (MDS), classified according to FAB system. In RA we have not revealed any important karyotype abnormalities. In patients with RAEB we have detected monosomy 7, considered an unfavourable prognostic sign. There was found an unidentified marker chromosome in the patient with CMML. Diagnostic and prognostic value of karyotype investigation in MDS patients was discussed.
对按照FAB系统分类的骨髓增生异常综合征（MDS）患者进行了细胞遗传学研究，包括通过G显带和荧光原位杂交（FISH）分析Ph染色体的核型。在难治性贫血（RA）患者中，未发现任何重要的核型异常。在难治性贫血伴原始细胞过多（RAEB）患者中，检测到7号染色体单体，这被认为是一个不良预后指标。在慢性粒-单核细胞白血病（CMML）患者中发现了一条不明来源的标记染色体。讨论了核型研究在MDS患者中的诊断和预后价值。
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