Tomaszewski J, Miturski R, Semczuk A, Kotarski J, Jakowicki J
Kliniki Ginekologii Operacyjnej II Katedry Połoznictwa i Chorób Kobiecych AM w Lublinie.
Ginekol Pol. 1998 May;69(5):363-6.
Zearalenone (ZEA), a nonsteroidal mycotoxin with estrogen-like activity, is synthesized by molds (Fusarium) commonly contaminating poorly stored agricultural products and foodstuffs. Human ER binds ZEA and this is probable mechanism of its action, although their influence on target tissues seems to be weaker (80-160 less active) comparing to E2. Zea has been observed to possess tumor-promoting activity similar to that of estrogens and hypothetically can inducing proliferation and carcinogenesis in estrogen-dependent tissues. Nowadays, the questions are, if ZEA is present in human endometrium and whether concentrations of this mycoestrogen is associated with endometrial cell proliferation. Endometrial tissues specimens were collected from 49 women (endometrial adenocarcinoma n = 27, endometrial hyperplasia n = 11, normal proliferative endometrium n = 11). Mean tissue zearalenone concentration in 3 endometrial hyperplasia and 22 adenocarcinoma samples was 47.8 +/- +/- 6.48 and 167 +/- +/- 17.69 ng/ml respectively in contrary to normal endometrium where tissue mycoestrogen concentration was not detectable. In 8 cases of hyperplastic and 5 cases of neoplastic endometrial tissue specimens ZEA was not observed. Our findings confirm the presence of ZEA in hyperplastic and neoplastic endometrium and therefore this substance might be of importance in carcinogenesis.
玉米赤霉烯酮（ZEA）是一种具有雌激素样活性的非甾体类霉菌毒素，由通常污染储存不佳的农产品和食品的霉菌（镰刀菌）合成。人雌激素受体（ER）与ZEA结合，这可能是其作用机制，尽管与雌二醇（E2）相比，它们对靶组织的影响似乎较弱（活性低80 - 160倍）。已观察到ZEA具有与雌激素类似的促肿瘤活性，并且推测其可诱导雌激素依赖性组织中的细胞增殖和致癌作用。如今，问题在于ZEA是否存在于人类子宫内膜中，以及这种霉菌雌激素的浓度是否与子宫内膜细胞增殖有关。从49名女性中收集了子宫内膜组织样本（子宫内膜腺癌n = 27，子宫内膜增生n = 11，正常增殖期子宫内膜n = 11）。3例子宫内膜增生和22例腺癌样本中的组织玉米赤霉烯酮平均浓度分别为47.8±6.48和167±17.69 ng/ml，而正常子宫内膜组织中未检测到霉菌雌激素浓度。在8例增生性和5例肿瘤性子宫内膜组织样本中未观察到ZEA。我们的研究结果证实了ZEA在增生性和肿瘤性子宫内膜中的存在，因此这种物质可能在致癌过程中具有重要意义。
