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亚油酰胺的代谢。II. N-[α-苯基-β-(对甲苯基)乙基]亚油酰胺的吸收、分布、排泄及代谢

Metabolism of linoleamides. II. Absorption, distribution, excretion and metabolism of N-[alpha-phenyl-beta-(p-tolyl)ethyl]linoleamide.

作者信息

Nagata A

出版信息

Xenobiotica. 1976 Jun;6(6):339-44. doi: 10.3109/00498257609151645.

DOI:10.3109/00498257609151645
PMID:969561
Abstract
  1. Absorption, distribution, excretion and metabolism of (-)N-[alpha-phenyl-beta-(p-tolyl)ethyl][14C]linoleamide (14C-PTLA) were studied in rats and dogs. Faecal excretion of PTLA was studied in dogs and men by g.l.c. 2. 14C-PTLA (10 mg/kg) given orally to rats resulted in urinary and faecal excretion of radioactivity of 2 and 93%, respectively, by male rats and 8 and 87% by female rats in 48 h. Faecal excretion of PTLA in men was similar to that in rats. 3. Distribution of radioactivity in rats and dogs after oral administration of 14C-PTLA showed that a major part of the dose was not absorbed. 4. N-[alpha-phenyl-beta-(p-tolyl)ethyl]glutaric acid monoamide were detected in the urine of rats dosed orally with 14C-PTLA.
摘要
  1. 研究了(-)N-[α-苯基-β-(对甲苯基)乙基][¹⁴C]亚油酰胺(¹⁴C-PTLA)在大鼠和犬体内的吸收、分布、排泄及代谢情况。采用气相色谱法研究了犬和人体中PTLA的粪便排泄情况。2. 给大鼠口服¹⁴C-PTLA(10mg/kg)后，雄性大鼠在48小时内尿和粪便中放射性物质的排泄率分别为2%和93%，雌性大鼠分别为8%和87%。人体中PTLA的粪便排泄情况与大鼠相似。3. 口服¹⁴C-PTLA后，大鼠和犬体内放射性物质的分布情况表明，大部分剂量未被吸收。4. 在口服¹⁴C-PTLA的大鼠尿液中检测到了N-[α-苯基-β-(对甲苯基)乙基]戊二酸单酰胺。

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