Nagata A, Nakatani H, Toki K
Lipids. 1976 Mar;11(3):163-6. doi: 10.1007/BF02532852.
The effect of (-)N-[alpha-phenyl-beta-(p-tolyl)ethyl] linoleamide (PTLA) on intestinal absorption of cholesterol was studied in rats. Oral administration of 15 mg PTLA to rats resulted in a significant (P less than 0.05) decrease in the radioactivity in serum and liver 4 hr after administration of labeled cholesterol. The effect of PTLA was greater on the absorption of cholesteryl oleate as compared with free cholesterol. The rate of hydrolysis of cholesteryl oleate in mucosal homogenates of rat intestine was decreased with PTLA, suggesting that the inhibition of cholesterol absorption by PTLA is related to its effect on cholesteryl ester hydrolysis in the intestine.
研究了（-）N-[α-苯基-β-（对甲苯基）乙基]亚油酸酰胺（PTLA）对大鼠肠道胆固醇吸收的影响。给大鼠口服15毫克PTLA后，在给予标记胆固醇4小时后，血清和肝脏中的放射性显著（P<0.05）降低。与游离胆固醇相比，PTLA对油酸胆固醇酯吸收的影响更大。PTLA可降低大鼠肠道黏膜匀浆中油酸胆固醇酯的水解速率，这表明PTLA对胆固醇吸收的抑制作用与其对肠道胆固醇酯水解的影响有关。
