[作为环磷酰胺给药剂量和时间函数的对甲基化牛血清白蛋白迟发型超敏反应的变化]
[Variation in delayed hypersensitivity to methylated bovine serum albumin as as function of the dose and time of administration of cyclophosphamide].
作者信息
Drach G, Richard M F, Barbu E
出版信息
C R Acad Hebd Seances Acad Sci D. 1978 Mar 20;286(11):913-6.
PMID:96959
Abstract
The injection of Cy before immunization provokes an intensification of delayed-type hypersensitivity (DTH) to methylated bovine serum albumin (M-BSA) and a diminution of about 90% of the cell number in various lymphoid tissues. The relationship between these observations, the time of administration, the dose of injected Cy and the intensity of DTH reactions, allows us to formulate hypotheses concerning the physiological modulation of DTH.
摘要
免疫前注射环磷酰胺（Cy）会引发对甲基化牛血清白蛋白（M-BSA）的迟发型超敏反应（DTH）增强，并且各种淋巴组织中的细胞数量减少约90%。这些观察结果、给药时间、注射的Cy剂量与DTH反应强度之间的关系，使我们能够提出关于DTH生理调节的假设。
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