Antier D, Zhang B L, Poisson D, Pourcelot L, Sannajust F
JE MENESR-1991, Department of Neuropharmacology, Faculty of Pharmacy 31, Tours, France.
Neurosci Lett. 1998 Jun 26;250(1):57-60. doi: 10.1016/s0304-3940(98)00447-9.
No experimental studies looked at the disturbances appearing after a neonatal focal cerebral hypoxia-ischemia (HI) when animals become adults. Using radiotelemetry, we examined the effects of neonatal focal cerebral HI on blood pressure (BP), heart rate (HR), locomotor activity (LA), body temperature (BT) levels and circadian rhythm parameters of unrestrained adult Wistar rats. At 15 weeks of age, we continuously recorded the cardiovascular and neurobehavioral parameters of HI (n = 6) and sham-operated (n = 6) rats. In adult rats, HI induced persistent hypertensive effects associated with alteration in BP circadian rhythms and pronounced decreases in mesor and percent rhythm of LA. HR and BT parameters were not significantly modified. Therefore, our results suggest that the rat cardiovascular and behavioural circadian control systems may involve several structures which present selective vulnerability to early cerebral HI.
尚无实验研究观察新生动物局灶性脑缺氧缺血（HI）成年后出现的紊乱情况。我们采用无线电遥测技术，研究了新生动物局灶性脑HI对成年Wistar大鼠血压（BP）、心率（HR）、运动活动（LA）、体温（BT）水平及昼夜节律参数的影响。在15周龄时，我们持续记录HI组（n = 6）和假手术组（n = 6）大鼠的心血管和神经行为参数。在成年大鼠中，HI诱导了持续性高血压效应，伴有BP昼夜节律改变以及LA的中值和节律百分比显著降低。HR和BT参数未发生显著改变。因此，我们的结果表明，大鼠心血管和行为昼夜控制系统可能涉及多个对早期脑HI具有选择性易损性的结构。
