Bernal-Delgado E, Latour-Pérez J, Pradas-Arnal F, Gómez-López L I
Department of Preventive and Social Medicine, Faculty of Medicine, University of Zaragoza, Spain.
Fertil Steril. 1998 Aug;70(2):191-200. doi: 10.1016/s0015-0282(98)00142-3.
To evaluate the possible association between vasectomy and prostate cancer.
Systematic review of the literature.
PATIENT(S): Fourteen original studies published between January 1985 and December 1996 that addressed the association between vasectomy and prostate cancer.
MAIN OUTCOME MEASURE(S): The strength of the association was estimated with the use of a meta-analysis (DerSimonian and Laird method). A sensitivity analysis was conducted to assess the impact of different sources of heterogeneity.
RESULT(S): Fourteen original papers were reviewed (5 cohort and 9 case-control studies). Relative risks ranged between 0.44 (95% confidence interval [CI] = 0.1-4.0) and 6.70 (95% CI = 2.1-21.6). The overall relative risk (DerSimonian and Laird estimate) was 1.23 (95% CI = 1.01-1.49). The sensitivity analysis showed that this measure was very sensitive to the study base, the type of design used, and the possibility of bias. Further, the funnel plot demonstrated the probable existence of publication bias.
CONCLUSION(S): No causal association was found between vasectomy and prostate cancer. Individuals who have undergone vasectomy are not at high risk for the development of prostate cancer.
评估输精管切除术与前列腺癌之间可能存在的关联。
文献系统综述。
1985年1月至1996年12月期间发表的14项关于输精管切除术与前列腺癌关联的原创性研究。
采用荟萃分析（DerSimonian和Laird方法）估计关联强度。进行敏感性分析以评估不同异质性来源的影响。
回顾了14篇原创论文（5项队列研究和9项病例对照研究）。相对风险在0.44（95%置信区间[CI]=0.1 - 4.0）至6.70（95%CI = 2.1 - 21.6）之间。总体相对风险（DerSimonian和Laird估计值）为1.23（95%CI = 1.01 - 1.49）。敏感性分析表明，该指标对研究基础、所用设计类型和偏倚可能性非常敏感。此外，漏斗图显示可能存在发表偏倚。
未发现输精管切除术与前列腺癌之间存在因果关联。接受输精管切除术的个体患前列腺癌的风险不高。
