Vercueil L, Benazzouz A, Deransart C, Bressand K, Marescaux C, Depaulis A, Benabid A L
U398 INSERM, Faculté de Médecine, Strasbourg, France.
Epilepsy Res. 1998 Jun;31(1):39-46. doi: 10.1016/s0920-1211(98)00011-4.
High-frequency electrical stimulation of deep brain structures has recently been developed for the surgical approach of neurologic disorders. Applied to the thalamus in tremors or to the subthalamic nucleus in Parkinson's disease, high-frequency stimulation has been demonstrated to exert a local inhibiting influence, leading to symptoms alleviation. In the present study, bilateral high-frequency stimulations (130 Hz) of the subthalamic nuclei suppressed ongoing spontaneous absence seizures in rats. This effect was dissociated from motor side-effects and appears specific to the subthalamic nucleus. Bilateral excitotoxic lesions of the subthalamic nuclei only partially suppressed absence-seizures. These results confirm the involvement of the basal ganglia system in the control of generalized seizures and suggest that high-frequency stimulations could be used in the treatment of some forms of seizures.
深部脑结构的高频电刺激最近已被开发用于神经系统疾病的外科治疗方法。高频刺激应用于震颤患者的丘脑或帕金森病患者的丘脑底核，已被证明可发挥局部抑制作用，从而减轻症状。在本研究中，双侧高频刺激（130Hz）丘脑底核可抑制大鼠正在进行的自发性失神发作。这种效应与运动副作用无关，且似乎是丘脑底核特有的。双侧丘脑底核的兴奋性毒性损伤仅部分抑制失神发作。这些结果证实了基底神经节系统参与全身性癫痫的控制，并表明高频刺激可用于治疗某些形式的癫痫。
