Noachtar S, von Maydell B, Fuhry L, Büttner U
Department of Neurology, University of Munich, Germany.
Epilepsy Res. 1998 Jun;31(1):47-57. doi: 10.1016/s0920-1211(98)00015-1.
This prospective study examined the effects of the new antiepileptic drug (AED) gabapentin (GBP) compared to the standard AED carbamazepine (CBZ) and placebo (PLA) on eye movements, posture and finger force control in 12 healthy volunteers who received single doses of 600 mg GBP and 400 mg CBZ in a placebo-controlled, double-blind, cross-over, randomized trial. CBZ and GBP reduced almost equally (8% vs. 10%) the mean peak saccade velocity as compared to PLA (P < 0.05). CBZ, but not GBP, significantly prolonged the duration of saccades as compared to placebo (14-24%) (P < 0.05). GBP produced a greater maximal increase of body sway than CBZ with eyes open (P < 0.01) and eyes closed (P < 0.001). CBZ and GBP did not significantly influence control of grip force. CBZ effects were better correlated with plasma levels. Subjective side effects were more pronounced with CBZ than GBP. Although CBZ and GBP cause similar CNS side effects, the effects on eye movements and body sway were different. CBZ predominantly affects saccadic eye movements, whereas GBP had more impact on posture control. Thus, electro-oculography seems to be more appropriate in the detection of CBZ-induced side effects and posturography appears to be more sensitive in the detection of side effects associated with GBP.
这项前瞻性研究在一项安慰剂对照、双盲、交叉、随机试验中，对12名健康志愿者单剂量服用600毫克加巴喷丁（GBP）、400毫克卡马西平（CBZ）和安慰剂（PLA）后，新抗癫痫药物（AED）加巴喷丁（GBP）与标准AED卡马西平（CBZ）及安慰剂（PLA）对眼球运动、姿势和手指力量控制的影响进行了研究。与PLA相比，CBZ和GBP使平均扫视峰值速度降低程度几乎相同（分别为8%和10%）（P<0.05）。与安慰剂相比，CBZ可显著延长扫视持续时间（14%-24%）（P<0.05），而GBP无此作用。睁眼（P<0.01）和闭眼（P<0.001）时，GBP比CBZ产生更大的身体摆动最大增加幅度。CBZ和GBP对握力控制无显著影响。CBZ的效应与血浆水平相关性更好。CBZ的主观副作用比GBP更明显。尽管CBZ和GBP引起相似的中枢神经系统副作用，但它们对眼球运动和身体摆动的影响不同。CBZ主要影响眼球扫视运动，而GBP对姿势控制影响更大。因此，眼电图似乎更适合检测CBZ引起的副作用，而姿势描记法在检测与GBP相关的副作用方面似乎更敏感。
