Quaglia M G, Farina A, Bossu E, Dell'Aquila C
Dipartimento di Studi Farmaceutici, Università, La Sapienza, Roma, Italy.
J Pharm Biomed Anal. 1995 Apr;13(4-5):505-9. doi: 10.1016/0731-7085(95)01340-q.
A simple capillary electrophoretic method was developed for the analysis of a new generation of serotonergic anxiolytics and their related substances: zalospirone, gepirone, ipsapirone and buspirone. All compounds run in a Tris/phosphate buffer at pH 3 as cations and the experimental conditions allowed good resolution of four drugs and their principal impurities. The analyses were made using two different kinds of capillary. The suitability of CZE and HPLC methods for the analysis of these non-benzodiazepinic anxiolytic agents and their impurities was compared.
