大肠杆菌饥饿基因cstC参与氨基酸分解代谢。
The Escherichia coli starvation gene cstC is involved in amino acid catabolism.
作者信息
Fraley C D, Kim J H, McCann M P, Matin A
机构信息
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA.
出版信息
J Bacteriol. 1998 Aug;180(16):4287-90. doi: 10.1128/JB.180.16.4287-4290.1998.
Abstract
Escherichia coli strains mutant in the starvation gene cstC grow normally in a mineral salts medium but are impaired in utilizing amino acids as nitrogen sources. They are also compromised in starvation survival, where amino acid catabolism is important. The cstC gene encodes a 406-amino-acid protein that closely resembles the E. coli ArgD protein, which is involved in arginine biosynthesis. We postulate that CstC is a counterpart of ArgD in an amino acid catabolic pathway. The cstC upstream region contains several regulatory consensus sequences. Both sigmaS and sigma54 promoters are probably involved in cstC transcription and appear to compete with each other, presumably to match cstC expression to the cellular amino acid catabolic needs.
摘要
在饥饿基因cstC中发生突变的大肠杆菌菌株在矿物盐培养基中能正常生长，但在利用氨基酸作为氮源方面存在缺陷。在氨基酸分解代谢很重要的饥饿存活过程中，它们也受到损害。cstC基因编码一种406个氨基酸的蛋白质，该蛋白质与参与精氨酸生物合成的大肠杆菌ArgD蛋白非常相似。我们推测CstC是氨基酸分解代谢途径中ArgD的对应物。cstC上游区域包含几个调控共有序列。sigmaS和sigma54启动子可能都参与了cstC的转录，并且似乎相互竞争，大概是为了使cstC的表达与细胞氨基酸分解代谢需求相匹配。
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