人类核心启动子的鉴别研究。
A discrimination study of human core-promoters.
作者信息
Zhang M Q
机构信息
Cold Spring Harbor Laboratory, NY 11724, USA.
出版信息
Pac Symp Biocomput. 1998:240-51.
PMID:9697186
Abstract
A core-promoter, approximately from -60 bp upstream to +40 bp downstream of a RNA polymerase (RNAP) II transcription start site (TSS), binds to the preinitiation complex (PIC) and determine the position of TSS. Using position-specific k-tuple feature variables, a quadratic discriminant analysis (QDA) method is shown to be very effective in identifying human core-promoters.
摘要
核心启动子大约位于RNA聚合酶（RNAP）II转录起始位点（TSS）上游-60 bp至下游+40 bp的区域，它与预起始复合物（PIC）结合并确定TSS的位置。利用位置特异性k元组特征变量，二次判别分析（QDA）方法在识别人类核心启动子方面被证明非常有效。
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