Kim Y S, Chi H S, Ahn Y O, Lee H S, Klag M J
Department of Family Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Int J Epidemiol. 1998 Jun;27(3):525-9. doi: 10.1093/ije/27.3.525.
Although transmission of hepatitis C virus (HCV) through parental exposure is well documented, it is still controversial whether familial clustering of HCV occurs.
To investigate risk factors for HCV infection, 109 cases and 84 non-infected controls were studied. In addition, 250 family members (104 men, 146 women) of cases and 170 family members of controls (64 men, 106 women) were tested for HCV infection using an anti-HCV antibody, alanine aminotransferase (ALT), and reverse transcribed polymerase chain reaction (RT-PCR).
In the case-control analysis, people aged > or =60 were almost three times more likely to be infected by HCV than those aged <40. Risk of HCV infection was most strongly related to a history of blood transfusion (OR = 12.6, 95% CI: 4.3-36.5) followed by a history of jaundice (OR = 4.1, 95% CI: 1.3-12.6). Only one family member of cases and no-one related to the controls had HCV infection.
These results suggest that, in Korea, age and parenteral exposure, such as a blood transfusion, are risk factors for HCV infection and familial clustering of HCV infection, if it occurs, is rare.
虽然丙型肝炎病毒（HCV）经母婴传播已有充分记录，但HCV是否存在家族聚集性仍存在争议。
为研究HCV感染的危险因素，对109例病例和84例未感染对照进行了研究。此外，使用抗HCV抗体、丙氨酸转氨酶（ALT）和逆转录聚合酶链反应（RT-PCR）对病例组的250名家庭成员（104名男性，146名女性）和对照组的170名家庭成员（64名男性，106名女性）进行了HCV感染检测。
在病例对照分析中，年龄≥60岁的人感染HCV的可能性几乎是年龄＜40岁者的三倍。HCV感染风险与输血史（OR = 12.6，95%CI：4.3 - 36.5）最为相关，其次是黄疸史（OR = 4.1，95%CI：1.3 - 12.6）。病例组仅有一名家庭成员感染HCV，对照组无相关感染者。
这些结果表明，在韩国，年龄和诸如输血等非肠道暴露是HCV感染的危险因素，且HCV感染的家族聚集性即便存在也很罕见。
