Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, No. 11 Xizhimen South Street, Beijing, 100044, China.
BMC Public Health. 2018 Jun 7;18(1):708. doi: 10.1186/s12889-018-5592-5.
Hepatitis C is a curable disease, but reinfection from household contact may occur in patients who have achieved sustained viral response (SVR).
A total of 997 ethnic Han HCV treatment-naïve adult patients were enrolled in a cross-sectional study with stratified sampling based on the populations of five geographic regions across China to examine the genetic and physiological parameters associated with the phenomenon of HCV familial clustering.
Of the total 997 patients, there were 59 patients who had at least one family member with HCV infection according to patient self-report. Comparison between patients with and without HCV familial clustering by univariate regression analysis showed that genotype 2, sexual transmission, long-term exposure to HCV patients, monthly family income per person less than 2000 yuan, farming occupation, and the southern and northern regions were associated with HCV familial clustering. Blood transfusion was negatively associated with HCV familial clustering. Multivariate logistic regression analysis suggested that long-term exposure to HCV patients and low family income were correlated with HCV familial clustering, whereas blood transfusion was negatively associated, which meant that blood transfusion was not the main transmission route in HCV familial clustering.
Long-term exposure to HCV patients and low family income were correlated with HCV familial clustering, whereas blood transfusion was not the main transmission route in HCV familial clustering. To reduce reinfection from household contacts, education and awareness of HCV transmission routes and familial clustering should be strengthened, especially among HCV patients' family members, low-income families and non-blood transmission hepatitis C patients.
丙型肝炎是一种可治愈的疾病，但在实现持续病毒应答（SVR）的患者中，可能会因家庭接触而再次感染。
采用基于中国五个地理区域人群的分层抽样方法，对 997 名汉族丙型肝炎初治成年患者进行了横断面研究，以探讨与丙型肝炎家族聚集现象相关的遗传和生理参数。
在 997 例患者中，根据患者自述，有 59 例至少有一位家庭成员患有 HCV 感染。通过单因素回归分析比较有和无 HCV 家族聚集的患者，结果显示基因型 2、性传播、长期接触 HCV 患者、人均月家庭收入低于 2000 元、务农职业以及南方和北方地区与 HCV 家族聚集有关。输血与 HCV 家族聚集呈负相关。多因素 logistic 回归分析表明，长期接触 HCV 患者和家庭收入低与 HCV 家族聚集相关，而输血呈负相关，这意味着输血不是 HCV 家族聚集的主要传播途径。
长期接触 HCV 患者和家庭收入低与 HCV 家族聚集有关，而输血不是 HCV 家族聚集的主要传播途径。为了减少家庭接触的再感染，应加强对 HCV 传播途径和家族聚集的教育和认识，特别是在 HCV 患者的家庭成员、低收入家庭和非血液传播的丙型肝炎患者中。
