Canali C, Goulart A H, Graeff-Teixeira C
Laboratório de Parasitologia, Curso de Pós-Graduação em Biociências, Insituto de Biociências, Faculdade de medicina, PUCRS, Porto Alegre, RS, Brasil.
Mem Inst Oswaldo Cruz. 1998 Mar-Apr;93(2):269-72. doi: 10.1590/s0074-02761998000200026.
Abdominal angiostrongylosis is a nematode infection wild rodents. Human infection may result in severe abdominal disease and has been reported from several countries in the Americas. The domestic mouse, Mus musculus, has not been found with natural infection and, like other urban rodents, should not be considered a natural host for Angiostrongylus costaricensis. Quantification of parasitic forms released for transmission may better express the coevolutionary status in parasite-host relationship. With this objective, five groups of experimentally infected Swiss mice were followed for up to 155 days post-infection (PI) days and the quantification of first stage larvae (L1) output revealed: an irregular elimination of L1 and a huge variation in the patency period (1 to 114 days) and in the number of L1 eliminated daily by individual animals (1 to 6340 L1/g). Overall mortality was 72% (range: 28% to 100%) at seven weeks PI. In conclusion, abdominal angiostrongylosis in M. musculus presents high mortality and a very variable and irregular elimination of L1 in feces.
腹部管圆线虫病是一种野生啮齿动物的线虫感染。人类感染可能导致严重的腹部疾病，美洲的几个国家都有相关报道。家鼠（小家鼠）未被发现有自然感染情况，并且与其他城市啮齿动物一样，不应被视为哥斯达黎加管圆线虫的自然宿主。对用于传播的寄生虫形态进行定量分析可能更能体现寄生虫与宿主关系中的共同进化状态。出于这一目的，对五组实验感染的瑞士小鼠进行了长达感染后155天的跟踪观察，对第一期幼虫（L1）排出量的定量分析显示：L1的排出不规则，排虫期（1至114天）以及个体动物每日排出的L1数量（1至6340条L1/克）差异巨大。感染后7周时的总体死亡率为72%（范围：28%至100%）。总之，小家鼠的腹部管圆线虫病死亡率高，粪便中L1的排出非常多变且不规则。
