Martinsen E W, Raglin J S, Hoffart A, Friis S
Department of Psychiatry, Central Hospital of Sogn og Fjordane, Førde, Norway.
J Anxiety Disord. 1998 Jul-Aug;12(4):333-42. doi: 10.1016/s0887-6185(98)00018-8.
We wanted to test the tolerance of intensive exercise and corresponding high levels of lactate in patients with panic disorder. Thirty-five consecutive patients with DSM-III-R panic disorder completed submaximal tests, and 24 completed additional supramaximal exercise tests. All experienced high values of lactate during the supramaximal test (M = 10.7 mmol/L, SD = 2.9), but only 1 patient experienced a panic attack. The blood lactate values in the present study were higher than the usually achieved values of 5 to 6 mmol/L during infusion. In general, 67% of patients panic during infusion, compared to 4% in the present study. This discrepancy in frequency of panic following exposure to endogenous and exogenous lactate is discussed on the basis of various hypotheses of panic disorder, with an emphasis on cognitive theory of panic. The study indicates that patients with panic disorder can safely undergo vigorous exercise of such intensity to result in significant lactate production, with the chances of panic being small.
我们想要测试惊恐障碍患者对高强度运动及相应高水平乳酸的耐受性。35名连续的DSM-III-R惊恐障碍患者完成了次最大量测试，24名患者完成了额外的最大量运动测试。所有患者在最大量测试期间都经历了高乳酸值（M = 10.7 mmol/L，标准差 = 2.9），但只有1名患者经历了惊恐发作。本研究中的血乳酸值高于输注期间通常达到的5至6 mmol/L的值。一般来说，67%的患者在输注期间会惊恐，而本研究中这一比例为4%。基于惊恐障碍的各种假说，尤其是惊恐的认知理论，讨论了内源性和外源性乳酸暴露后惊恐频率的这种差异。该研究表明，惊恐障碍患者能够安全地进行如此强度的剧烈运动，从而产生大量乳酸，惊恐发作的几率很小。
