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香烟烟雾的SH反应性及其对仓鼠肺组织培养物致癌作用的相关性。

SH Reactivity of cigarette smoke and its correlation with carcinogenic effects on hamster lung cultures.

作者信息

Leuchtenberger C, Leuchtenberger R, Zbinden I, Schleh E

出版信息

Soz Praventivmed. 1976 Jan-Feb;21(1):47-50. doi: 10.1007/BF01994377.

DOI:10.1007/BF01994377
PMID:969919
Abstract

After hamster lung cultures were exposed repeatedly to puffs of fresh smoke from 7 types of cigarettes containing variable amounts of particulate and gas vapour phase components, atypical growth and/or malignant cell transformation were observed within a period of 3-6 months. A positive correlation was demonstrable between high SH reactivity and high NO content of the gas vapour phase and malignant transformation. There was no positive correlation for the other analyzed components of the smoke, including tar content.

摘要

将仓鼠肺组织培养物反复暴露于7种含有不同数量颗粒相和气相成分的香烟所产生的新鲜烟雾中后，在3至6个月内观察到了非典型生长和/或恶性细胞转化。气相中高硫氢（SH）反应性和高一氧化氮（NO）含量与恶性转化之间存在明显的正相关。对于烟雾中其他分析成分，包括焦油含量，未发现正相关。

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本文引用的文献

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Inhibiting effect of tobacco smoke on some crystalline enzymes.烟草烟雾对某些结晶酶的抑制作用。
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The mechanism of carcinogenesis by tobacco smoke. Further experimental evidence and a prediction from the thiol-defence hypothesis.烟草烟雾致癌的机制。进一步的实验证据及基于硫醇防御假说的预测。
L-半胱氨酸或维生素C对仓鼠肺组织培养物免受烟草或大麻卷烟新鲜烟雾致癌作用的保护作用。
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Nature. 1974 Feb 22;247(5442):565-7. doi: 10.1038/247565a0.
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Nature. 1973 Apr 6;242(5397):403-4. doi: 10.1038/242403a0.
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Effects of marijuana and tobacco smoke on human lung physiology.大麻烟雾和烟草烟雾对人体肺部生理的影响。
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