真核生物中的基因簇与多顺反子转录
Gene clusters and polycistronic transcription in eukaryotes.
作者信息
Blumenthal T
机构信息
Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver 80262, USA.
出版信息
Bioessays. 1998 Jun;20(6):480-7. doi: 10.1002/(SICI)1521-1878(199806)20:6<480::AID-BIES6>3.0.CO;2-Q.
Abstract
Sometimes genes are arranged nonrandomly on the chromosomes of eukaryotes. This review considers instances of gene clusters in which two genes or more are expressed from a single promoter. This includes cases in which a polycistronic pre-mRNA is processed to make monocistronic mRNAs in nematodes, as well as isolated examples of polycistronic mRNAs found in mammals, flies, and perhaps plants.
摘要
有时，真核生物染色体上的基因呈非随机排列。本综述探讨了基因簇的实例，其中两个或更多基因由单个启动子表达。这包括线虫中多顺反子前体mRNA被加工成单顺反子mRNA的情况，以及在哺乳动物、果蝇甚至可能在植物中发现的多顺反子mRNA的个别例子。
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