Wouters R J, van den Bosch W A, Lemij H G
Department of Oculoplastic Surgery, The Rotterdam Eye Hospital, The Netherlands.
Invest Ophthalmol Vis Sci. 1998 Aug;39(9):1544-50.
To describe the saccades made by patients with Graves' disease (GD) and to attempt to distinguish these objectively and quantitatively from the saccades in control subjects.
In 12 euthyroid patients with GD, the saccades of both eyes were recorded simultaneously with electromagnetic search coils. Subjects were asked to alternate their gazes between two fixed targets that were 10 degrees, 20 degrees, 30 degrees, or 40 degrees apart along each horizontal or vertical meridian. The data from the patients with GD and those from the similarly recorded group of 12 control subjects were examined in two ways. First, the difference in saccadic sizes between the two eyes was assessed. Second, the saccadic dynamics--that is, the maximum velocity and the saturation constant of the main sequence--were determined for each eye. Repeated measurement analysis of variance was used to test observed differences between the two groups. Finally, through exact logistic regression analysis, classification of the saccades as those of a patient with GD or of a control subject was carried out.
The saccades of patients with GD were generally less conjugate than those of control subjects (P < 0.05). On average, the maximum main sequence velocities in patients with GD were lower than in control subjects (P < 0.05). The saccades of patients with GD were well differentiated from those of control subjects.
The saccades in GD may differ markedly from normal saccades, and the two can be reliably distinguished.
描述格雷夫斯病（GD）患者的扫视运动，并试图客观、定量地将其与对照组受试者的扫视运动区分开来。
对12例甲状腺功能正常的GD患者，使用电磁搜索线圈同时记录双眼的扫视运动。要求受试者沿着每条水平或垂直子午线在相距10度、20度、30度或40度的两个固定目标之间交替注视。对GD患者和同样记录的12名对照组受试者的数据进行了两种方式的检查。首先，评估双眼扫视幅度的差异。其次，确定每只眼睛的扫视动力学，即主序列的最大速度和饱和常数。采用重复测量方差分析来检验两组之间观察到的差异。最后，通过精确逻辑回归分析，将扫视运动分类为GD患者或对照组受试者的扫视运动。
GD患者的扫视运动通常比对照组受试者的扫视运动协调性更差（P < 0.05）。平均而言，GD患者的主序列最大速度低于对照组受试者（P < 0.05）。GD患者的扫视运动与对照组受试者的扫视运动有明显区别。
GD患者的扫视运动可能与正常扫视运动有显著差异，并且两者可以可靠地区分。
