Monzawa K, Kido T, Yamaya H, Kobayashi E, Nogawa K
Department of Hygiene, Chiba University School of Medicine, Inohana, Japan.
Toxicology. 1998 May 15;127(1-3):187-93. doi: 10.1016/s0300-483x(98)00044-4.
The urinary excretion levels of sodium (Na) and potassium (K) in cadmium (Cd)-exposed subjects as related with urinary beta2-microglobulin (beta2-MG) and Cd concentrations were investigated. The target population comprised of 3164 inhabitants of Japan who were more than 50 years of age and who lived in cadmium-polluted areas and 294 inhabitants who lived in non-polluted areas of Japan. A significant increase in urinary excretion of K was shown in Cd-exposed subjects although there was no significant difference in urinary excretion of Na between the Cd-exposed and non-exposed subjects. Urinary K concentrations in both sexes were significantly correlated with age, urinary beta2-MG and Cd concentrations by multiple regression analysis. Urinary Na concentration was significantly correlated with age, beta2-MG and Cd in men, but in women it was significantly associated with only the urinary beta2-MG concentration. The present study demonstrated that increased K excretion was a more sensitive effect of cadmium exposure than increased Na excretion.
研究了镉（Cd）暴露人群尿中钠（Na）和钾（K）的排泄水平与尿β2-微球蛋白（β2-MG）及镉浓度的关系。目标人群包括3164名年龄超过50岁、居住在镉污染地区的日本居民以及294名居住在日本非污染地区的居民。镉暴露人群的尿钾排泄量显著增加，尽管镉暴露组与未暴露组的尿钠排泄量无显著差异。多元回归分析显示，男女尿钾浓度均与年龄、尿β2-MG及镉浓度显著相关。男性尿钠浓度与年龄、β2-MG及镉显著相关，而女性尿钠浓度仅与尿β2-MG浓度显著相关。本研究表明，与尿钠排泄增加相比，尿钾排泄增加是镉暴露更敏感的效应。
