Westermarck S, Juppo A M, Kervinen L, Yliruusi J
Orion Corporation, Espoo, Finland.
Eur J Pharm Biopharm. 1998 Jul;46(1):61-8. doi: 10.1016/s0939-6411(97)00169-0.
Two methods used in pore structure characterisation, mercury porosimetry and nitrogen adsorption, were compared. Pore structure and surface area of mannitol powder, granules produced in wet granulation and tablets compressed with three compression pressures were studied. Greater surface area, more porous structure and greater number of small pores in granules, when compared with powder, increased the compactibility of mannitol granules in tableting. Plastic deformation and fragmentation of powder and granules in compression were observed in volume pore size distributions and surface areas measured with these methods. Pore volume and volume pore size distribution obtained with mercury porosimetry describe densification of mass better than those obtained with nitrogen adsorption. In spite of differences between the methods, the volume pore size distribution curves of samples in the overlapping pore size range had the same shape. The specific surface area of tablets, measured by the nitrogen gas adsorption method described well the deformation under compression. Fragmentation increased the surface area of powder, and plastic deformation decreased the surface area of granules in the pore size range determined. Surface area values measured with mercury porosimetry were larger than those determined with nitrogen adsorption.
对用于孔隙结构表征的两种方法——压汞法和氮气吸附法进行了比较。研究了甘露醇粉末、湿法制粒生产的颗粒以及在三种压片压力下压制成的片剂的孔隙结构和表面积。与粉末相比，颗粒具有更大的表面积、更多孔的结构以及更多的小孔，这增加了甘露醇颗粒在压片时的可压性。通过这些方法测量的体积孔径分布和表面积观察到了粉末和颗粒在压缩过程中的塑性变形和破碎。压汞法获得的孔体积和体积孔径分布比氮气吸附法获得的更能描述物料的致密化情况。尽管方法之间存在差异，但在重叠孔径范围内样品的体积孔径分布曲线形状相同。用氮气吸附法测得的片剂比表面积很好地描述了压缩过程中的变形情况。破碎增加了粉末的表面积，而塑性变形在确定的孔径范围内减小了颗粒的表面积。用压汞法测得的表面积值大于用氮气吸附法测得的值。
