Willenheimer R, Erhardt L, Eskilsson J
Hjärtkliniken, Universitetssjukhuset MAS, Malmö.
Lakartidningen. 1998 Jul 8;95(28-29):3183-7.
Post-infarction prognosis is considerably impaired if left ventricular systolic dysfunction and/or symptomatic heart failure develops. As the symptoms of left ventricular dysfunction are often subtle or completely lacking, such patients can be identified only by objective evaluation of left ventricular function. However, as symptoms of heart failure may develop despite normal left ventricular function, objective evaluation of left ventricular function is also important in symptomatic patients, since prognosis is especially poor in the presence of systolic dysfunction. As echocardiography is the most suitable and accessible method in the context, also allowing assessment of cardiac dimensions and valvular function, its extended use in post-infarction patients is imperative. Left ventricular dysfunction should be prevented by adequate measures to limit the extent of infarction and prevent its recurrence. To improve prognosis, the use of ACE (angiotensin converting enzyme) inhibitors should be considered whenever left ventricular dysfunction is present, irrespective of symptomatology. Treatment with amiodarone has recently been shown to reduce mortality among patients with post-infarction heart failure, and should also be considered in such cases, especially if there is a need of antiarrhythmic therapy. Although beta-receptor blockers have well-documented beneficial effects in myocardial infarction, their effect on patients with latent or overt heart failure has not been specifically studied. The use of angiotensin II antagonists in patients with post-infarction heart failure or left ventricular dysfunction is currently under investigation.
如果发生左心室收缩功能障碍和/或出现症状性心力衰竭,心肌梗死后的预后会受到严重损害。由于左心室功能障碍的症状往往不明显或完全没有,这类患者只能通过对左心室功能的客观评估来识别。然而,尽管左心室功能正常,但心力衰竭症状仍可能出现,因此对有症状患者进行左心室功能的客观评估也很重要,因为存在收缩功能障碍时预后尤其不佳。鉴于超声心动图是这种情况下最合适且最易实施的方法,还能评估心脏大小和瓣膜功能,因此在心肌梗死后患者中广泛应用超声心动图势在必行。应采取适当措施限制梗死范围并防止其复发,以预防左心室功能障碍。为改善预后,只要存在左心室功能障碍,无论有无症状,都应考虑使用血管紧张素转换酶(ACE)抑制剂。最近研究表明,胺碘酮治疗可降低心肌梗死后心力衰竭患者的死亡率,在这种情况下也应考虑使用,尤其是在需要抗心律失常治疗时。尽管β受体阻滞剂在心肌梗死中有确凿的有益作用,但它们对潜在或显性心力衰竭患者的影响尚未进行专门研究。目前正在研究血管紧张素II拮抗剂在心肌梗死后心力衰竭或左心室功能障碍患者中的应用。