[Influence of uncoupling agents on the capacity of transamidinase in kidney and pancreas].

It was found in white rats that hyperthyreosis (0.5% thyreoidin in dry food), respectively 2,4-dinitrophenol (30 mg/kg body weight/day i. p.), deficiency of the vitamins K and E or complete fasting increase the content of creatine in muscle, plasma and urine, but reduce the concentration of creatinine. Simultaneously the elevated creatine level of blood causes a repression of transamidinase in kidneys and pancreas. The common mode of action of the mentioned agents is seen in a decoupling of the oxidative phosphorylation, and in an insufficient availability of ATP, respectively.