Medvinsky A L, Dzierzak E A
Erasmus University, Medical Faculty, Department of Cell Biology and Genetics, Rotterdam, The Netherlands.
Dev Comp Immunol. 1998 May-Jun;22(3):289-301. doi: 10.1016/s0145-305x(98)00007-x.
Recent research on the ontogeny of the hematopoietic system in mammals has shown that a simple textbook steady-state hematopoietic hierarchy can not be strictly applied to the hematopoietic cells found within the embryo. During embryonic development, hematopoietic cells originate, migrate and differentiate in a number of distinct anatomical sites such as the yolk sac AGM region and liver and thus represent various classes of cells within diverse microenvironments. In this manuscript we review both cellular and molecular aspects of developmental hematopoiesis and present our current views on the numerous complex mechanisms underlying the establishment of definitive hematopoiesis.
最近对哺乳动物造血系统个体发育的研究表明，简单的教科书式稳态造血层级不能严格应用于胚胎内发现的造血细胞。在胚胎发育过程中，造血细胞在多个不同的解剖部位（如卵黄囊、主动脉-性腺-中肾区和肝脏）起源、迁移和分化，因此代表了不同微环境中的各类细胞。在本手稿中，我们综述了发育性造血的细胞和分子方面，并就确定性造血建立背后的众多复杂机制提出了我们目前的观点。
