Gonzalez M I, Baker B I, Hole D R, Wilson C A
Department Obstetrics and Gynaecology, St. George's Hospital Medical School, London, UK.
Peptides. 1998;19(6):1007-16. doi: 10.1016/s0196-9781(98)00045-x.
The behavioral and neurochemical effects of NEI, and its interaction with alpha-MSH or MCH were investigated in the ventromedial nucleus (VMN) and medial preoptic area (MPOA) in female rats (bilateral administration, 100 ng in 0.5 microliter/side). NEI in the VMN (but not in the MPOA) stimulated exploratory behavior, increased anxiety and reduced dopamine and DOPAC release. The behavioral effects were antagonized by alpha-MSH. NEI stimulated female sexual receptivity in the MPOA. In the VMN, NEI did not have any effect on sexual activity, but partially antagonized the stimulatory effect of MCH. These results show that NEI in the hypothalamus participates in the regulation of behavior, possibly through dopaminergic mediation.
在雌性大鼠的腹内侧核（VMN）和内侧视前区（MPOA）（双侧给药，每侧0.5微升含100纳克）研究了神经内分泌免疫调节肽（NEI）的行为和神经化学效应，以及它与α-促黑素（α-MSH）或促黑素细胞激素（MCH）的相互作用。VMN中的NEI（而非MPOA中的）刺激探索行为、增加焦虑并减少多巴胺和二羟基苯乙酸（DOPAC）的释放。α-MSH可拮抗这些行为效应。NEI刺激MPOA中的雌性性接受能力。在VMN中，NEI对性活动没有任何影响，但部分拮抗了MCH的刺激作用。这些结果表明，下丘脑的NEI可能通过多巴胺能介导参与行为调节
