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[兔回避反应过程中内侧下丘脑的功能不对称性]

[The functional asymmetry of the rabbit medial hypothalamus during the avoidance reaction].

作者信息

Pavlova I V

机构信息

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 May-Jun;48(3):396-404.

PMID:9700902
Abstract

Thresholds of avoidance reactions and changes in correlated neuronal activity in the visual and sensorimotor cortical areas were studied in rabbits under conditions of stimulation of right (RH) and left (LH) medial hypothalamus. Avoidance threshold were lower during stimulation of the LH (112 +/- 12 mcA) than during stimulation of the RH (166 +/- 22 mcA). The stimulation of LH was more effective in inducing reorganization in correlated activity of neurons: only after the left stimulation (inducing active avoidance) the number of neuronal pairs with correlated activity in the left hemisphere increased (49%) and delays up to 120 ms appeared between the discharges of visual and sensorimotor cortical neurons (the first one led). The obtained evidence suggests the more important role of the LH than RH in motivation.

摘要

在对家兔右侧(RH)和左侧(LH)内侧下丘脑进行刺激的条件下,研究了视觉和感觉运动皮层区域的回避反应阈值以及相关神经元活动的变化。刺激LH时的回避阈值(112±12毫安)低于刺激RH时的回避阈值(166±22毫安)。刺激LH在诱导神经元相关活动的重组方面更有效:仅在左侧刺激(诱导主动回避)后,左半球中具有相关活动的神经元对数量增加(49%),并且在视觉和感觉运动皮层神经元放电之间出现了长达120毫秒的延迟(第一个神经元先放电)。所获得的证据表明,LH在动机方面比RH发挥着更重要的作用。

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