[神经毒素AF64A对神经症化大鼠反应的作用]
[The action of the neurotoxin AF64A on the reactions of neuroticized rats].
作者信息
Aĭrapetiants M G, Levshina I P, Nozdracheva L V, Shuĭkin N N
机构信息
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
出版信息
Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 May-Jun;48(3):534-40.
The effects of intracerebroventricular administration of ethylholine aziridinum ion (AF64A) were studied in neuroticized male Wistar rats. The cholinotoxin was bilaterally injected in the dose of 3 nmol. AF64A produced a significant decrease in arterial pressure and activity of respiratory enzymes succinate dehydrogenase and NADH-dehydrogenase in hippocampus and motor cortex. Increase in the local blood flow in the hippocampus and motor cortex had a compensatory character.
在神经症化的雄性Wistar大鼠中研究了脑室内注射氮丙啶离子乙基胆碱（AF64A）的作用。以3 nmol的剂量双侧注射胆碱毒素。AF64A使动脉血压以及海马体和运动皮层中呼吸酶琥珀酸脱氢酶和NADH脱氢酶的活性显著降低。海马体和运动皮层局部血流的增加具有代偿性质。
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