Moreau T, Sochurkova D, Lemesle M, Madinier G, Billiar T, Giroud M, Dumas R
Neurophysiological Laboratory, Hôpital Croix Rousse, Lyon, France.
Epilepsia. 1998 Aug;39(8):893-6. doi: 10.1111/j.1528-1157.1998.tb01187.x.
To determine potential mechanisms of epilepsy in patients with multiple sclerosis (MS).
Among 402 patients with clinically and radiologically defined MS, including de novo cases, presenting to the Neurology Service, University Hospital of Dijon, we identified 17 with epileptic seizures (4.25%). Among them, the percentage with partial seizures (50%) was greater than that in the reference population.
In most of the patients with MS, plaques were localized in the frontal region, associated with frontal and callosal atrophy, a frontal syndrome, and severe disability status (as assessed by a standard scale). Magnetic resonance imaging (MRI) showed numerous subcortical plaques. Seizures generally were well controlled with antiepileptic drugs (AEDs).
Our data suggest that the subcortical plaques of MS underlie seizure activity in patients with MS and epilepsy.
确定多发性硬化症（MS）患者癫痫发作的潜在机制。
在第戎大学医院神经科就诊的402例临床和影像学确诊的MS患者（包括初发病例）中，我们识别出17例有癫痫发作（4.25%）。其中，部分性发作患者的比例（50%）高于参考人群。
大多数MS患者的斑块位于额叶区域，伴有额叶和胼胝体萎缩、额叶综合征以及严重残疾状态（通过标准量表评估）。磁共振成像（MRI）显示大量皮质下斑块。癫痫发作一般用抗癫痫药物（AEDs）能得到很好的控制。
我们的数据表明，MS的皮质下斑块是MS合并癫痫患者癫痫发作活动的基础。
