Hansen A J
Acta Physiol Scand. 1976 Aug;97(4):519-22. doi: 10.1111/j.1748-1716.1976.tb10292.x.
The potassium concentration in the cisternal cerebrospinal fluid (CSF) was measured following brain ischemia in rats of different ages which has been kept at normoxia or pretreated with hypoxia (PIO2 = 70 mmHg) for 24 h. In all age groups the potassium concentration rose following ischemia. The rate of rise was relatively slow in the 4-day rat and faster in 16- and 24-day rats; beyond this age the rate of rise became slower. Pretreatment with hypoxia significantly diminished the rate of rise in CSF potassium in 4- and 8-day rats, while no effect was observed in the older age groups. It is suggested that the rate of rise in CSF potassium is inversely correlated with the capacity of surviving a period of oxygen deprivation.
在不同年龄的大鼠脑缺血后，测量其脑池脑脊液（CSF）中的钾浓度。这些大鼠被置于常氧环境或预先用低氧（动脉血氧分压 = 70 mmHg）处理24小时。在所有年龄组中，缺血后脑脊液钾浓度均升高。4日龄大鼠的升高速率相对较慢，16日龄和24日龄大鼠的升高速率较快；超过这个年龄后，升高速率变慢。低氧预处理显著降低了4日龄和8日龄大鼠脑脊液钾的升高速率，而在年龄较大的组中未观察到影响。提示脑脊液钾的升高速率与缺氧一段时间后的存活能力呈负相关。
