Misiura K, Wójcik M, Krakowiak A, Koziołkiewicz M, Pawłowska Z, Pluskota E, Cierniewski C S, Stec W J
Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lódź.
Acta Biochim Pol. 1998;45(1):27-32.
Dimethoxytritylphosphono-oligonucleotide conjugates have been prepared. They are totally resistant to nucleases present in human serum and do not affect cleavage of a complementary oligoribonucleotide by RNase H. Conjugates possessing a phosphate backbone gave better antisense inhibition of expression of plasminogen activator inhibitor type-1 within endothelial cells as compared with unconjugated oligonucleotides.
