Saksela M, Lapatto R, Raivio K O
Hospital for Children and Adolescents, University of Helsinki, Finland.
Biol Neonate. 1998 Oct;74(4):274-80. doi: 10.1159/000014034.
Xanthine oxidoreductase (XOR) has been implicated in tissue injury following ischemia-reperfusion because of its ability to generate reactive oxygen species under these conditions. In order to elucidate its role in various organs, we quantified the levels of XOR mRNA expression and activity in developing human tissues. XOR gene expression was highest in the intestine and in the liver, which also showed the highest enzyme activities. By a sensitive RNA-PCR assay, low levels of the transcript were detected in the kidney, lung, cardiac muscle, and brain of all subjects studied. XOR activities followed the mRNA distribution, being low or undetectable in tissues other than the liver and the intestine.
黄嘌呤氧化还原酶（XOR）因在缺血再灌注后能够产生活性氧而与组织损伤有关。为了阐明其在各个器官中的作用，我们对发育中的人体组织中的XOR mRNA表达水平和活性进行了定量。XOR基因表达在肠道和肝脏中最高，这两个器官也表现出最高的酶活性。通过灵敏的RNA-PCR检测，在所有研究对象的肾脏、肺、心肌和大脑中均检测到低水平的转录本。XOR活性与mRNA分布一致，在肝脏和肠道以外的组织中活性较低或无法检测到。
