Ponomareva N V, Fokin V F, Selesneva N D, Voskresenskaia N I
Brain Research Institute, Research Centre for Mental Health, Moscow, Russia.
Dement Geriatr Cogn Disord. 1998 Sep-Oct;9(5):267-73. doi: 10.1159/000017071.
Visual-evoked potentials (VEP) to a flash were studied in the first-order relatives of patients with Alzheimer's disease (AD) (mean age 38.2 +/- 2.6 years) in comparison with the patients (mean age 61.9 +/- 1.4 years) and age-matched normal controls. It was found that in the relatives of AD patients the latencies of N2, P3, N3 components were delayed compared with the age-matched normal controls. The delay in the latencies of the patients and their relatives concerned the same components but was smaller in the relatives of AD patients. The amplitude of the P2, N2 components was increased in the latter. The neurophysiological alteration in AD patients' relatives may be considered as signs of a latent neurodegeneration in limbico-reticulo-cortical pathways, which may be connected to the pathological hyperactivity of limbico-reticulo-cortical structures.
对阿尔茨海默病（AD）患者的一级亲属（平均年龄38.2±2.6岁）进行了闪光视觉诱发电位（VEP）研究，并与患者（平均年龄61.9±1.4岁）及年龄匹配的正常对照者进行比较。结果发现，与年龄匹配的正常对照者相比，AD患者亲属中N2、P3、N3成分的潜伏期延迟。患者及其亲属潜伏期的延迟涉及相同成分，但在AD患者亲属中延迟较小。后者中P2、N2成分的波幅增加。AD患者亲属的神经生理改变可被视为边缘-网状-皮质通路潜在神经变性的迹象，这可能与边缘-网状-皮质结构的病理性活动亢进有关。
