Ponomareva N V, Fokin V F, Selezneva N D
Vestn Ross Akad Med Nauk. 1999(1):16-20.
Visual evoked potentials versus flash (VEP) and brain DC-potentials were studied in the first-order relatives of patients (mean age 42.6 +/- 1.6 years) with Alzheimer's disease (AD) and probands (mean age 60.9 +/- 0.9 years) and age-matched healthy controls for the relatives and probands. In the relatives of AD patients, the latencies of N2, P3, N3 components were found to be delayed as compared with the controls. There was a delay in the latencies of the same components in the patients and their relatives, but it was smaller in the relatives of AD patients. The brain DC-potentials were higher in the relatives of AD patients than in the controls. Neurophysiological changes in the relatives of AD patients may be considered to be signs of latent neurodegeneration in the limbicoreticulocortical pathways, which may be associated with the excitotoxic processes and abnormal hyperactivity in the limbicoreticulocortical structures.
对阿尔茨海默病（AD）患者（平均年龄60.9±0.9岁）及其一级亲属（平均年龄42.6±1.6岁）以及与亲属和先证者年龄匹配的健康对照者进行了视觉诱发电位与闪光（VEP）及脑直流电位的研究。在AD患者的亲属中，发现N2、P3、N3成分的潜伏期与对照组相比有所延迟。患者及其亲属中相同成分的潜伏期均有延迟，但AD患者亲属中的延迟较小。AD患者亲属的脑直流电位高于对照组。AD患者亲属的神经生理变化可被认为是边缘网状皮质通路潜在神经变性的迹象，这可能与边缘网状皮质结构中的兴奋毒性过程和异常多动有关。
