Kaziro Y
Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology.
Nihon Rinsho. 1998 Jul;56(7):1651-7.
Extracellular signals are recognized by the receptors on the surface of cytoplasmic membrane and are transmitted through the complex array of intracellular signal transduction networks. Through recent advances in molecular and genetic analyses, we are beginning to understand the outline of the signaling machineries leading from receptors to targets at molecular level. This review intends to describe the general characteristics of receptors and components of intra-cellular signal transduction systems. Future prospects of the studies on signal transduction in medicine are also discussed.
细胞外信号由细胞质膜表面的受体识别,并通过细胞内信号转导网络的复杂阵列进行传递。通过分子和遗传分析的最新进展,我们开始在分子水平上理解从受体到靶标的信号传导机制的概况。本综述旨在描述受体的一般特征和细胞内信号转导系统的组成部分。还讨论了医学信号转导研究的未来前景。