Taga T
Department of Molecular Cell Biology, Tokyo Medical and Dental University.
Nihon Rinsho. 1998 Jul;56(7):1674-80.
As a tool to investigate physiological and pathological roles of cytokines, gene manipulation techniques have been applied to make mouse models having mutations in cytokine receptor genes. Functional pleiotropy and redundancy are two major characteristic features of cytokines. The latter feature is in part explained by the shared usage of a signal-transducing receptor component by several cytokine receptor complexes. In this article, studies with the help of gene manipulation techniques on a group of cytokine receptor complexes sharing the signal transducer, gp130, are reviewed. To investigate the in vivo roles of gp130, mice deficient for gp130 or having constitutively activated gp130 were made. Transgenic mice expressing a dominant-negative form of gp130 were produced as well. Observation from these mouse models and that from mice deficient for other gp130-related receptors and ligans are also reviewed in this article.
作为研究细胞因子生理和病理作用的一种工具，基因操作技术已被应用于构建细胞因子受体基因发生突变的小鼠模型。功能多效性和冗余性是细胞因子的两个主要特征。后一个特征部分是由几种细胞因子受体复合物对信号转导受体成分的共同使用来解释的。在本文中，我们综述了借助基因操作技术对一组共享信号转导子gp130的细胞因子受体复合物所进行的研究。为了研究gp130在体内的作用，制备了gp130缺陷或组成性激活gp130的小鼠。还制备了表达显性负性形式gp130的转基因小鼠。本文还综述了从这些小鼠模型以及从其他gp130相关受体和配体缺陷小鼠所获得的观察结果。
