某些N-苯磺酰基-2-(2-或3-吡啶基乙基)-苯并咪唑的合成、抗病毒及抗增殖活性
Synthesis, antiviral and antiproliferative activity of some N-benzenesulphonyl-2(2- or 3-pyridylethyl)-benzimidazoles.
作者信息
Garuti L, Roberti M, Rossi T, Cermelli C, Portolani M, Malagoli M, Castelli M
机构信息
Department of Pharmaceutical Science, University of Bologna, Italy.
出版信息
Anticancer Drug Des. 1998 Jul;13(5):397-406.
Some N-benzenesulphonyl-2(2- or 3-pyridylethyl)-benzimidazoles were synthesized and tested in vitro for antiproliferative and antiviral activity. Only one compound displayed a degree of antiproliferative activity against chronic myeloid leukaemia cells. However, a number of them exerted an antiviral effect at micromolar concentrations. The antiproliferative activity and the maximum potency of antiviral activity correlate with the presence of both the 2-pyridyl moiety bound at the ethylenic bridge in C-2 of benzimidazole and the nitro group in the benzene ring.
合成了一些N-苯磺酰基-2(2-或3-吡啶基乙基)苯并咪唑，并在体外测试了其抗增殖和抗病毒活性。只有一种化合物对慢性髓性白血病细胞表现出一定程度的抗增殖活性。然而，其中一些化合物在微摩尔浓度下具有抗病毒作用。抗增殖活性和抗病毒活性的最大效力与苯并咪唑C-2位烯桥处连接的2-吡啶基部分和苯环中的硝基的存在相关。
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