咪唑并[1,2 - a]吡啶和嘧啶系列无环C - 核苷作为抗病毒剂的合成。
Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.
作者信息
Gueiffier A, Lhassani M, Elhakmaoui A, Snoeck R, Andrei G, Chavignon O, Teulade J C, Kerbal A, Essassi E M, Debouzy J C, Witvrouw M, Blache Y, Balzarini J, De Clercq E, Chapat J P
机构信息
Laboratoire de Chimie Organique Pharmaceutique, URA-CNRS 1111, Montpellier, France.
出版信息
J Med Chem. 1996 Jul 5;39(14):2856-9. doi: 10.1021/jm9507901.
PMID:8709116
Abstract
The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.
摘要
报道了咪唑并[1,2-a]吡啶和嘧啶的C-3无环核苷类似物的合成及其抗病毒活性。从这些化合物中，20、21、22、23、28和34对巨细胞病毒和/或水痘带状疱疹病毒显示出特异性活性。
Zotero 插件