Amlie J P, Langmark F, Storstein O
Acta Med Scand. 1976;200(3):201-8.
The varied etiology of pure mitral regurgitation is demonstrated in this clinicopathological study, comprising 59 surgically treated cases with this condition. One third of the cases was of rheumatic origin, one fifth had ischemic heart disease, another fifth floppy valves and one eighth an isolated rupture of the chordae with necrosis of the chord matrix. To our knowledge the histopathological findings in the last group have not been described before. Congenital mitral regurgitation, bacterial endocarditis and cardiomyopathy were rare causes of mitral regurgitation. Differences between the groups were observed in the sex ratio, duration of history, auscultatory findings ECG signs, compliance of the left ventricle and in the morphological findings.
本临床病理研究展示了单纯二尖瓣反流的多种病因，该研究纳入了59例接受手术治疗的此病患者。三分之一的病例为风湿性病因，五分之一患有缺血性心脏病，另有五分之一为瓣膜脱垂，八分之一为腱索孤立性断裂并伴有腱索基质坏死。据我们所知，最后一组的组织病理学发现此前尚未见报道。先天性二尖瓣反流、细菌性心内膜炎和心肌病是二尖瓣反流的罕见病因。在性别比例、病史时长、听诊结果、心电图体征、左心室顺应性以及形态学发现等方面观察到了各组之间的差异。
