关于厌氧菌，尤其是二路普雷沃菌在大鼠子宫积脓模型中的致病性研究。
Studies on the pathogenicity of anaerobes, especially Prevotella bivia, in a rat pyometra model.
作者信息
Mikamo H, Kawazoe K, Izumi K, Watanabe K, Ueno K, Tamaya T
机构信息
Department of Obstetrics and Gynecology, School of Medicine, Gifu University, Japan.
出版信息
Infect Dis Obstet Gynecol. 1998;6(2):61-5. doi: 10.1002/(SICI)1098-0997(1998)6:2<61::AID-IDOG6>3.0.CO;2-A.
OBJECTIVE
Prevotella bivia is one of the anaerobic bacteria that resides in the flora of the female genital tract. We studied the pathogenicity of P. bivia in a rat pyometra model.
METHODS
The experimental animal (rat) model of pyometra was developed to investigate the pathogenicity of P. bivia in a rat pyometra model.
RESULTS
In the groups inoculated with aerobes alone, the infection rate was 10% (1/10) in the Staphylococcus aureus- or Staphylococcus agalactiae-inoculated group and 20% (2/10) in the Escherichia coli-inoculated group. Infection was not established in the groups inoculated with anaerobes alone. High infection rates were observed in all the mixed-infection groups. In the S. agalactiae- and Bacteroides fragilis-, S. agalactiae- and P. bivia-, F. coli- and B. fragilis-, and E. coli- and P. bivia-inoculated groups, an infection rate of 100% (10/10) was demonstrated. The efficacy of antibiotics such as flomoxef (FMOX) could be determined using a rat pyometra model. In relation to the alteration of vaginal microbial flora during the menstrual cycle, estrogen increased the growth of P. bivia.
CONCLUSION
Mixture of aerobic bacteria and P. bivia increased the pathogenicity of P. bivia. Estrogen would be useful for raising up the inflammatory change of the uterus in experimental models of genital tract infection due to P. bivia.
目的
二路普雷沃菌是一种存在于女性生殖道菌群中的厌氧菌。我们在大鼠子宫积脓模型中研究了二路普雷沃菌的致病性。
方法
建立子宫积脓的实验动物（大鼠）模型，以研究二路普雷沃菌在大鼠子宫积脓模型中的致病性。
结果
在仅接种需氧菌的组中，接种金黄色葡萄球菌或无乳链球菌的组感染率为10%（1/10），接种大肠杆菌的组感染率为20%（2/10）。仅接种厌氧菌的组未发生感染。在所有混合感染组中均观察到高感染率。在接种无乳链球菌和脆弱拟杆菌、无乳链球菌和二路普雷沃菌、大肠杆菌和脆弱拟杆菌以及大肠杆菌和二路普雷沃菌的组中，感染率均为100%（10/10）。可以使用大鼠子宫积脓模型来确定氟氧头孢（FMOX）等抗生素的疗效。关于月经周期中阴道微生物群的变化，雌激素会增加二路普雷沃菌的生长。
结论
需氧菌与二路普雷沃菌的混合增加了二路普雷沃菌的致病性。在二路普雷沃菌引起的生殖道感染实验模型中，雌激素有助于加剧子宫的炎症变化。
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