Bartlett J G, Dezfulian M, Joiner K
Arch Surg. 1983 Feb;118(2):181-4. doi: 10.1001/archsurg.1983.01390020037006.
Activity of seven antimicrobial agents was examined using a mouse model of a subcutaneous infection that involved Bacteroides fragilis. Untreated mice had encapsulated abscesses with approximately 10(10) bacteria. Pharmacokinetic studies showed that all drugs tested penetrated into abscesses to provide mean peak levels that were 17% to 53% of mean peak serum levels. In vivo efficacy v 15 strains was measured by the reduction in counts of viable organisms when treatment was initiated one hour after challenge. This showed that the most active agents, in order of activity, were metronidazole hydrochloride, clindamycin phosphate, moxalactam disodium, and cefoxitin sodium. A delay in treatment of eight to 120 hours after challenge showed a noticeable reduction in activity, except with metronidazole. It is presumed that bacteria within an abscess are in a stationary growth phase, and this has an important influence on in vivo efficacy.
使用涉及脆弱拟杆菌的皮下感染小鼠模型，检测了七种抗菌剂的活性。未经治疗的小鼠有包囊脓肿，其中约有10(10)个细菌。药代动力学研究表明，所有测试药物均能渗透到脓肿中，平均峰值水平为平均血清峰值水平的17%至53%。在攻击后1小时开始治疗时，通过活生物体数量的减少来测量对15株菌株的体内疗效。结果表明，活性最高的药物依次为盐酸甲硝唑、磷酸克林霉素、二钠莫拉卡坦和头孢西丁钠。攻击后8至120小时延迟治疗显示活性明显降低，但甲硝唑除外。据推测，脓肿内的细菌处于静止生长阶段，这对体内疗效有重要影响。
