Abiko Y, Muramatsu T, Tanaka Y, Ohuchi T, Satoh M, Okumura K, Shibata T, Inoue T, Kanazawa M, Arisue M, Shimono M, Kaku T
Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Pathol Int. 1998 Jun;48(6):460-6. doi: 10.1111/j.1440-1827.1998.tb03933.x.
Two cases of basaloid-squamous cell carcinoma (BSC) of the oral mucosa are described. The first case occurred at the floor of the mouth in a 58-year-old man, and the second case occurred at the mandibular gingiva in a 79-year-old woman. The laboratory data of the first case showed a positive response to hepatitis C virus antibody. In the first case, the tumor mass measured 4 x 4 cm in size, and was located at the lingual side of the median mandible beside the sublingual gland. In the second case, the tumor mass measured 25 x 15 mm in size, and was located in the alveolar mucosa of the right mandible. Histologically, both tumors showed a neoplastic epithelium arranged in a solid pattern with evidence of peripheral palisading, central necrosis, and some squamous differentiation. The proliferative activities of the BSC were compared with conventional squamous cell carcinomas (SCC) in the oral floor and gingiva, respectively, by employing a sensitive argyrophilic nuclear organizer region (AgNOR) staining method. The number of AgNOR per nucleus of the BSC was higher than that of any other SCC cases. The results support the opinion that BSC of the oral mucosa has a worse prognosis than conventional SCC.
本文描述了两例口腔黏膜基底样鳞状细胞癌（BSC）。第一例发生在一名58岁男性的口底，第二例发生在一名79岁女性的下颌牙龈。第一例的实验室数据显示丙型肝炎病毒抗体呈阳性反应。第一例中，肿瘤肿块大小为4×4厘米，位于下颌骨中线舌侧、舌下腺旁。第二例中，肿瘤肿块大小为25×15毫米，位于右下颌牙槽黏膜。组织学上，两个肿瘤均显示肿瘤上皮呈实性排列，有周边栅栏状、中央坏死及一些鳞状分化的证据。通过采用灵敏的嗜银核仁组成区（AgNOR）染色方法，分别将口底和牙龈的BSC增殖活性与传统鳞状细胞癌（SCC）进行比较。BSC每个细胞核的AgNOR数量高于任何其他SCC病例。结果支持口腔黏膜BSC比传统SCC预后更差的观点。
