Andersson A C, Henningsson S, Lundell L, Rosengren E, Sundler F
Agents Actions. 1976 Sep;6(5):577-83. doi: 10.1007/BF01971572.
In female rats, mammary carcinoma were induced by DMBA (7,12-dimethylbenz(alpha)anthracene) administration. The activities of histidine and ornithine decarboxylases and the concentrations of histamine, putrescine and polyamines were determined in tumour extracts and urine. In the tumour tissue, formation of histamine and putrescine took place at much higher rates than in normal mammary tissue. Administration of compound 48/80 in doses that mobilized about 70% of histamine contained in the ear failed to release histamine contained in the tumour; 48/80 also failed to produce histological signs of degranulation of the tumour mast cells. It thus appears that these cells are different from mast cells in most normal tissues, a distinction that calls for further study.
在雌性大鼠中，通过给予DMBA（7,12 - 二甲基苯并(α)蒽）诱导乳腺癌。测定了肿瘤提取物和尿液中组氨酸脱羧酶和鸟氨酸脱羧酶的活性以及组胺、腐胺和多胺的浓度。在肿瘤组织中，组胺和腐胺的形成速率比正常乳腺组织高得多。给予能动员耳部约70%组胺的剂量的化合物48/80，未能释放肿瘤中的组胺；48/80也未能产生肿瘤肥大细胞脱颗粒的组织学迹象。因此，这些细胞似乎与大多数正常组织中的肥大细胞不同，这一区别需要进一步研究。
