化合物48/80体外刺激大鼠肥大细胞中组胺的合成。

Stimulation of histamine synthesis in rat mast cells by compound 48/80 in vitro.

作者信息

Rothschild A M, Fortunato I C

出版信息

Experientia. 1984 Oct 15;40(10):1151-2. doi: 10.1007/BF01971468.

DOI:10.1007/BF01971468

PMID:6208052

Abstract

The histamine content of rat peritoneal fluid cells is doubled within 20 min by 0.5 microgram/ml of compound 48/80. Histamine catabolism inhibitors do not reproduce this effect; cells pre-incubated with alpha-fluoromethylhistidine are unresponsive to compound 48/80 which therefore activates pre-formed histidine decarboxylase rather than 'inducing' it. Non-mast cells showed no change after treatment with compound 48/80.

摘要

每毫升含0.5微克的化合物48/80可使大鼠腹腔液细胞中的组胺含量在20分钟内增加一倍。组胺分解代谢抑制剂无法重现这种效应；用α-氟甲基组氨酸预孵育的细胞对化合物48/80无反应，因此化合物48/80激活的是预先形成的组氨酸脱羧酶，而非“诱导”其形成。用化合物48/80处理后，非肥大细胞无变化。