Britton B J, Wood W G, Smith M, Hawkey C, Irving M H
Thromb Haemost. 1976 Apr 30;35(2):396-402.
Exercise stress is known to stimulate blood coagulation and fibrinolysis possibly as a result of sympatho-adrenal stimulation of the beta adrenergic receptor. In order to test this hypothesis five men exercised on four separate occasions with and without prior beta adrenergic blockade with oxprenolol, propranolol and pindolol. The increase in plasma adrenaline and noradrenaline concentration was much greater during exercise under beta blockade but activation of fibrinolysis was enhanced as well. Factor VIII levels did not change significantly during any of the experiments. These results suggest that the activation of fibrinolysis by exercise is not mediated by the beta adrenergic receptor. The influence of beta adrenergic blockade on the change in factor VIII with exercise was inconclusive.
已知运动应激可能由于β肾上腺素能受体的交感-肾上腺刺激而刺激血液凝固和纤维蛋白溶解。为了验证这一假设，五名男性在有和没有预先使用氧烯洛尔、普萘洛尔和吲哚洛尔进行β肾上腺素能阻滞的情况下，分别进行了四次运动。在β阻滞下运动期间，血浆肾上腺素和去甲肾上腺素浓度的增加要大得多，但纤维蛋白溶解的激活也增强了。在任何实验中，因子VIII水平均无显著变化。这些结果表明，运动对纤维蛋白溶解的激活不是由β肾上腺素能受体介导的。β肾上腺素能阻滞对运动时因子VIII变化的影响尚无定论。
