Butler M J, Smith M, Irving M H, Gordon Y B, Ratky S M, Rivers J W, Hawkey C
Thromb Diath Haemorrh. 1975 Sep 30;34(1):169-80.
Twenty volunteers were assessed for baseline coagulation (Thrombelastography, Factor VIII and platelet count) and fibrinolytic (Euglobulin Lysis Time and Fibrin(ogen) Degradation Products) activity two hours after ingestion of 60 mgm propranolol or an identical placebo administered on a double blind basis. The responses of these parameters to a fifteen minute period of venous occlusion was also assessed. Beta adrenergic blockade reduced baseline FDP titres but did not affect other parameters, nor the local response to venous occlusion. During occlusion no significant change in coagulation activity could be detected in the non-occluded arm, but a small but statistically significant shortening of ELT was observed. Since this effect was prevented by propranolol it is probably mediated through adrenergic mechanisms. Adrenergic stimuli appear to influence episodes of coagulation and fibrinolysis during everyday activity, but do not contribute to baseline levels of coagulation or fibrinolytic function.
20名志愿者在双盲基础上摄入60毫克普萘洛尔或相同安慰剂两小时后，接受了基线凝血（血栓弹力图、凝血因子VIII和血小板计数）和纤维蛋白溶解（优球蛋白溶解时间和纤维蛋白（原）降解产物）活性评估。还评估了这些参数对15分钟静脉阻塞期的反应。β肾上腺素能阻断降低了基线FDP水平，但不影响其他参数，也不影响对静脉阻塞的局部反应。在阻塞期间，未阻塞手臂的凝血活性未检测到显著变化，但观察到ELT有小幅但具有统计学意义的缩短。由于这种效应被普萘洛尔阻止，它可能是通过肾上腺素能机制介导的。肾上腺素能刺激似乎在日常活动中影响凝血和纤维蛋白溶解过程，但对凝血或纤维蛋白溶解功能的基线水平没有影响。
