Kling P J, Roberts R A, Widness J A
Department of Pediatrics, The University of Arizona, Steele Memorial Children's Research Center, Tucson 85724, USA.
J Pediatr Hematol Oncol. 1998 Jul-Aug;20(4):309-14. doi: 10.1097/00043426-199807000-00005.
The goal of this study was to determine if the postnatal changes in plasma transferrin receptor (TfR) levels in healthy infants were associated with changes in erythropoiesis or iron status.
Longitudinal blood samples were obtained monthly from healthy term infants fed iron-fortified formula for the first 7 months and analyzed for plasma TfR and indices of erythropoiesis and iron status.
Plasma TfR level rose during the first 2 months of life (p < 0.002). When examined for its association with indices of erythropoiesis, plasma TfR was negatively associated with hemoglobin (Hb) (p < 0.01), and positively associated with plasma erythropoietin (EPO) concentration (p < 0.005) and absolute reticulocyte count (p < 0.005). Plasma TfR was not associated with erythrocyte protoporphyrin. Although indices of iron status were not suggestive of iron deficiency, plasma TfR was negatively associated with plasma ferritin, Tf saturation, and plasma iron, and positively associated with total iron binding capacity (TIBC) (p < 0.0001 for all).
Increases in plasma TfR levels were observed during normal infancy. The increases in plasma TfR levels correlate with increases in erythropoiesis without evidence for functional iron deficiency.
本研究的目的是确定健康婴儿出生后血浆转铁蛋白受体（TfR）水平的变化是否与红细胞生成或铁状态的变化相关。
对健康足月儿在出生后的前7个月每月采集纵向血样，这些婴儿喂养铁强化配方奶粉，并对血浆TfR、红细胞生成指标和铁状态进行分析。
血浆TfR水平在出生后的前2个月升高（p < 0.002）。在研究其与红细胞生成指标的相关性时，血浆TfR与血红蛋白（Hb）呈负相关（p < 0.01），与血浆促红细胞生成素（EPO）浓度呈正相关（p < 0.005），与绝对网织红细胞计数呈正相关（p < 0.005）。血浆TfR与红细胞原卟啉无关。尽管铁状态指标未提示缺铁，但血浆TfR与血浆铁蛋白、转铁蛋白饱和度和血浆铁呈负相关，与总铁结合力（TIBC）呈正相关（所有p值均 < 0.0001）。
在正常婴儿期观察到血浆TfR水平升高。血浆TfR水平的升高与红细胞生成增加相关，且无功能性缺铁的证据。
