大样本场循环式光泵磁共振成像仪的设计、构建与应用

Design, construction and use of a large-sample field-cycled PEDRI imager.

作者信息

Lurie D J, Foster M A, Yeung D, Hutchison J M

机构信息

Department of Biomedical Physics and Bioengineering, University of Aberdeen, Foresterhill, UK.

出版信息

Phys Med Biol. 1998 Jul;43(7):1877-86. doi: 10.1088/0031-9155/43/7/008.

DOI:10.1088/0031-9155/43/7/008

PMID:9703050

Abstract

The design, construction and use of a large-scale field-cycled proton-electron double-resonance imaging (FC-PEDRI) imager is described. The imager is based on a whole-body sized, vertical field, 59 mT permanent magnet. Field cycling is accomplished by the field compensation method, and uses a secondary, resistive magnet with an internal diameter of 52 cm. The magnetic field can be switched from zero to 59 mT or vice versa in 40 ms. It is used with a double-resonance coil assembly (NMR/EPR) comprising a solenoidal NMR transmit/receive coil and a coaxial, external birdcage resonator for EPR irradiation. Experiments to image the distribution of an exogenous nitroxide free radical in anaesthetized rabbits are described.

摘要

本文描述了一种大型场循环质子 - 电子双共振成像（FC - PEDRI）成像仪的设计、构造和使用。该成像仪基于一个全身尺寸的垂直磁场、59 mT的永磁体。场循环通过场补偿方法实现，并使用一个内径为52 cm的次级电阻磁体。磁场可在40 ms内从零切换到59 mT或反之。它与一个双共振线圈组件（NMR/EPR）配合使用，该组件包括一个螺线管NMR发射/接收线圈和一个用于EPR照射的同轴外部鸟笼式谐振器。文中还描述了对麻醉兔体内外源性氮氧自由基分布进行成像的实验。