体内电子顺磁共振的药物应用。

Pharmaceutical applications of in vivo EPR.

作者信息

Mäder K

机构信息

Philipps University Marburg, Department of Pharmaceutics and Biopharmacy, Germany.

出版信息

Phys Med Biol. 1998 Jul;43(7):1931-5. doi: 10.1088/0031-9155/43/7/014.

DOI:10.1088/0031-9155/43/7/014

PMID:9703056

Abstract

The aim of this article is to discuss the applications of in vivo EPR in the field of pharmacy. In addition to direct detection of free radical metabolites and measurement of oxygen, EPR can be used to characterize the mechanisms of drug release from biodegradable polymers. Unique information about drug concentration, the microenvironment (viscosity, polarity, pH) and biodistribution (by localized measurement or EPR Imaging) can be obtained.

摘要

本文的目的是讨论体内电子顺磁共振（EPR）在药学领域的应用。除了直接检测自由基代谢物和测量氧气外，EPR还可用于表征药物从可生物降解聚合物中的释放机制。可以获得有关药物浓度、微环境（粘度、极性、pH值）和生物分布（通过局部测量或EPR成像）的独特信息。