Siebner H R, Dressnandt J, Auer C, Conrad B
Department of Neurology, Technical University of Munich, Germany.
Muscle Nerve. 1998 Sep;21(9):1209-12. doi: 10.1002/(sici)1097-4598(199809)21:9<1209::aid-mus15>3.0.co;2-m.
We observed a marked prolongation of the transcranially evoked silent period during continuous intrathecal administration of high doses of the gamma-aminobutyric acid (GABA)B receptor agonist baclofen in a patient with generalized dystonia. Size of motor evoked potentials and central conduction time remained unchanged during intrathecal baclofen administration. The selective prolongation of the silent period during high-dose continuous intrathecal baclofen therapy supports the notion that GABA(B)-ergic intracortical interneurons play a part in the generation of the transcranially evoked silent period.
在一名全身性肌张力障碍患者中，我们观察到在持续鞘内注射高剂量γ-氨基丁酸（GABA）B受体激动剂巴氯芬期间，经颅诱发的静息期显著延长。鞘内注射巴氯芬期间，运动诱发电位的大小和中枢传导时间保持不变。高剂量持续鞘内巴氯芬治疗期间静息期的选择性延长支持了GABA（B）能皮质内中间神经元在经颅诱发静息期的产生中起作用这一观点。
