[γ-氨基丁酸和吡拉西坦对实验性运动减少时脑和肝线粒体中ATP酶活性的影响]
[Effect of GABA and piracetam on on ATPase activity in brain and liver mitochondria in experimental hypokinesis].
作者信息
Akopian V P, Sotskiĭ O P, Mailian K R, Edigarova L V, Shafrazian D S, Vasilian A A
机构信息
Department of Pharmacology, Yerevan State Medical University, Armenia.
出版信息
Vopr Med Khim. 1998 May-Jun;44(3):262-6.
PMID:9703626
Abstract
Long-term hypokinesia is accompanied by changes in the activity of Mg(2+) and 2,4-dinitrophenol (DNP)-stimulated ATPases of rat brain and liver mitochondria. These changes are phasic and especially pronounced at periods characterised by most pronounced metabolic alterations Treatment of animals with GABA and piracetam tends to normalise the enzyme activities.
摘要
长期运动功能减退伴随着大鼠脑和肝线粒体中镁离子（Mg²⁺）以及2,4-二硝基苯酚（DNP）刺激的ATP酶活性的变化。这些变化是阶段性的，在代谢改变最为明显的时期尤为显著。用γ-氨基丁酸（GABA）和吡拉西坦治疗动物往往会使酶活性恢复正常。
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